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Gene Mutations May Cause Rare Neonatal Diabetes
Mutations in an insulin-linked gene can cause permanent neonatal diabetes, say American and U.K. researchers. They have identified 10 such mutations in 21 people from 16 families.
Permanent neonatal diabetes is a rare form of diabetes that affects infants and leads to lifelong dependence on insulin injections. This is the first study to link insulin gene mutations to severe diabetes with onset early in life, the researchers said. The mutations may influence the way insulin folds during its synthesis. These improperly folded proteins interfere then with other cellular processes in ways that eventually result in the death of cells that produce insulin, the researchers said.
The findings were published online by the journal Proceedings of the National Academy of Sciences and were expected to be in an upcoming print issue.
"This is a novel and potentially treatable cause of diabetes in infants," study author Dr. Louis Philipson, professor of medicine at the University of Chicago, said in a prepared statement.
This research "is exciting, because each of these patients has one normal insulin gene as well as one mutated gene. If we could detect the disease early enough and somehow silence the abnormal gene, or just protect insulin-producing cells from the damage caused by misfolding, we might be able to preserve or restore the patient's own insulin production," Philipson said.
Diabetes Mellitus Increases People's Vulnerability To Tuberculosis
Ref: Diabetes World, 24 July 2008 issue.
Diabetes mellitus increases a person's vulnerability to develop tuberculosis by around three times. Such a situation could give This could be the main reason for more than 10 percent of tuberculosis cases in India and China.
Researchers at the Harvard School of Public Health in Boston have examined data on 1.7 million people from 13 studies done in Canada, Mexico, the United States, Britain, Russia, Taiwan, India and South Korea in order to clarify links between diabetes and tuberculosis.
With around 250 million diabetics around the world, a figure which is expected to double by year 2020, it is obvious that diabetes is promoting the development and propagation of tuberculosis worldwide.
Diabetes predisposes people to tuberculosis infection and impairs their ability to respond to infection. So, it's all a question of the diabetic's immune system being considerably disabled.
One-third of the world's population is infected with Koch's bacillus that causes tuberculosis.
Tuberculosis kills about 1.7 million people every year, according to the World Health Organization.
Parasitology & Diabetes
All diabetics have a common fluke parasite, Eurytrema pancreaticum, the pancreatic fluke of cattle, in their own pancreas. Human beings get it repeatedly from cattle as they eat their meat or dairy products in a raw state. It is not hard to kill this parasite but humans can immediately be re-infected whilst re-eating cattle products.
However, Eurytrema pancreaticum will not settle and multiply in our pancreas without the presence of wood alcohol (methanol). Methanol pollution pervades our food supply: it is found in processed food stuffs, such as bottled water, artificial sweetener, soda pop, baby formula and powdered drinks of all kinds including health food varieties. Wood alcohol might be used to wash equipment used in manufacturing.
Therefore, diabetics should not use anything out of a can, package or bottle except regular milk, and, of course, no processed foods.
By killing this parasite and removing wood alcohol from the diet, the need for insulin can be cut to half in three weeks (or sooner).